abstract：:In this paper we present the studies on coordination abilities of two short-chain analogues of somatostatin with free N-terminal and protected amino group towards copper (II) ions. The octreotide is the most popular analogue of the somatostatin (peptide hormone) used in medicine. Somatostatin analogues are used in dia...

journal_title：Journal of inorganic biochemistry

authors： Marciniak A,Cebrat M,Czyżnikowska Ż,Brasuń J

更新日期：2012-12-01 00:00:00

abstract：:Methanobactins are copper-binding ligands produced by aerobic methanotrophic microorganisms. A quantitative understanding of their potential role in methanotrophic copper acquisition requires the investigation of their copper complexes under relevant pH conditions. In this study, a chemical speciation model describing...

journal_title：Journal of inorganic biochemistry

authors： Pesch ML,Christl I,Hoffmann M,Kraemer SM,Kretzschmar R

更新日期：2012-11-01 00:00:00

abstract：:The putative platinum(IV) anticancer drugs, [Pt{((R)NCH(2))(2)}(py)(2)XY] (X,Y=Cl, R=p-HC(6)F(4) (1a), C(6)F(5) (1b); X,Y=OH, R=p-HC(6)F(4) (2); X=Cl, Y=OH, R=p-HC(6)F(4) (3), py = pyridine) have been prepared by oxidation of the Pt(II) anticancer drugs [Pt{((R)NCH(2))(2)}(py)(2)] (R=p-HC(6)F(4) (4a) or C(6)F(5) (4b))...

journal_title：Journal of inorganic biochemistry

authors： Guo SX,Mason DN,Turland SA,Lawrenz ET,Kelly LC,Fallon GD,Gatehouse BM,Bond AM,Deacon GB,Battle AR,Hambley TW,Rainone S,Webster LK,Cullinane C

更新日期：2012-10-01 00:00:00

abstract：:Type 2 diabetes mellitus has been associated with obesity, metabolic syndrome, cardiovascular diseases and cancer. Attempts have been made for early diagnosis and finding effective drugs to prevent severe consequences and ameliorate the symptoms of this disorder. In this work, the pharmacological properties of VO(dmpp...

journal_title：Journal of inorganic biochemistry

authors： Metelo AM,Pérez-Carro R,Castro MM,López-Larrubia P

更新日期：2012-10-01 00:00:00

abstract：:Plastocyanin (PC) from poplar leaves is present in two isoforms, PCa and PCb, which differ in sequence by amino acid replacements at locations remote from the copper center and simultaneously act in the photosynthetic electron-transport chain. We describe ultra-high resolution structures of PCa and high-resolution str...

journal_title：Journal of inorganic biochemistry

authors： Kachalova GS,Shosheva AC,Bourenkov GP,Donchev AA,Dimitrov MI,Bartunik HD

更新日期：2012-10-01 00:00:00

abstract：:The short Cu(2+)-S(Met) bond in pseudoazurin (PAz) results in the presence of two relatively intense S(p)(π) and S(p)(σ) charge transfer (CT) transitions. This has enabled resonance Raman (rR) data to be obtained for each excited state. The rR data show very different intensity distribution patterns for the vibrations...

journal_title：Journal of inorganic biochemistry

authors： Hadt RG,Xie X,Pauleta SR,Moura I,Solomon EI

更新日期：2012-10-01 00:00:00

abstract：:The entire nirK gene coding for a putative copper-nitrite reductase (Nir) from Sinorhizobium meliloti 2011 (Sm) was cloned and overexpressed heterologously in Escherichia coli for the first time. The spectroscopic and molecular properties of the enzyme indicate that SmNir is a green Nir with homotrimeric structure (42...

journal_title：Journal of inorganic biochemistry

authors： Ferroni FM,Guerrero SA,Rizzi AC,Brondino CD

更新日期：2012-09-01 00:00:00

abstract：:The peptide sequence PHSRN is the second cell binding site of the human fibronectin protein, a glycoprotein which plays a critical adhesive role during development, tissue repair and angiogenesis. The copper(II) complexes with the peptide fragment PHSRN were characterized by potentiometric and UV-visible, CD, EPR spec...

journal_title：Journal of inorganic biochemistry

authors： Magrì A,D'Alessandro F,Distefano DA,Campagna T,Pappalardo G,Impellizzeri G,La Mendola D

更新日期：2012-08-01 00:00:00

abstract：:Changes in speciation of copper(II) in reactions with epigallocatechin gallate (EGCG) and gallic acid (GA) as a function of pH have been investigated by multifrequency (X- and S-band) EPR spectroscopy in the fluid and frozen states. The EPR spectra show the formation of three distinct mononuclear species with each of ...

journal_title：Journal of inorganic biochemistry

authors： Pirker KF,Baratto MC,Basosi R,Goodman BA

更新日期：2012-07-01 00:00:00

abstract：:The solution structure of Fe(II)-peplomycin was determined from NMR data collected for this molecule. As found previously for Fe(II)- and Co(II)-bound bleomycin; the coordination sphere of the metal is composed of the primary and secondary amines in β-aminoalanine, the pyrimidine and imidazole rings in the pyrimidinyl...

journal_title：Journal of inorganic biochemistry

authors： Li Y,Lehmann T

更新日期：2012-06-01 00:00:00

abstract：:Three amphiphilic antimony(V)-phthalocyanines have been synthesized by treating [Sb(R(4)Pc)(OH)(2)](+) salts in concentrated H(2)SO(4) and isolated as zwitter ions, [Sb(R(4)Pc)(SO(4)H)(SO(4))], where R(4)Pc denotes tetra-substituted phthalocyaninate; R(4)Pc=pc (R=H), tbpc (R=(t)Bu), and tObpc (R=O(n)Bu). Their solubil...

journal_title：Journal of inorganic biochemistry

authors： Isago H,Kagaya Y,Oyama Y,Fujita H,Sugimori T

更新日期：2012-06-01 00:00:00

abstract：:A large number of proteins contain bound zinc ions. These zinc ions are frequently coordinated by a combination of histidine and cysteine residues. In addition to atoms that coordinate directly to the zinc ions, these side chains have groups that can donate or accept hydrogen bonds from other groups. These secondary i...

journal_title：Journal of inorganic biochemistry

authors： Namuswe F,Berg JM

更新日期：2012-06-01 00:00:00

abstract：:In the presence of magnesium, enolase catalyzes the dehydration of 2-phospho-d-glycerate (PGA) to phosphoenolpyruvate (PEP) in glycolysis and the reverse reaction in gluconeogensis at comparable rates. The structure of human neuron specific enolase (hNSE) crystals soaked in PGA showed that the enzyme is active in the ...

journal_title：Journal of inorganic biochemistry

authors： Qin J,Chai G,Brewer JM,Lovelace LL,Lebioda L

更新日期：2012-06-01 00:00:00

abstract：:Cisplatin is one of the most widely used anticancer drugs. Its side effects, however, have motivated researchers to search for equally effective analogs that are better tolerated. Selectively targeting cancer tissue is one promising strategy. For this purpose, a platinum(IV) complex was conjugated to the cancer-target...

journal_title：Journal of inorganic biochemistry

authors： Graf N,Mokhtari TE,Papayannopoulos IA,Lippard SJ

更新日期：2012-05-01 00:00:00

abstract：:Solution behavior of levofloxacin (lvx) complexes with copper(II) in the presence and absence of phen was studied in aqueous solution, by potentiometry. The results obtained show that under physiological conditions (micromolar concentration range and pH 7.4) only copper(II):lvx:phen ternary complexes are stable. Hence...

journal_title：Journal of inorganic biochemistry

authors： Sousa I,Claro V,Pereira JL,Amaral AL,Cunha-Silva L,de Castro B,Feio MJ,Pereira E,Gameiro P

更新日期：2012-05-01 00:00:00

abstract：:Aluminum salts such as aluminum chlorohydrate (ACH) are known for use as an active antiperspirant agent that blocks the secretion of sweat. A local case report of hyperaluminemia in a woman using an aluminum-containing antiperspirant for 4 years raises the problem of transdermal absorption of aluminum (Al). Only a ver...

journal_title：Journal of inorganic biochemistry

authors： Pineau A,Guillard O,Favreau F,Marrauld A,Fauconneau B

更新日期：2012-05-01 00:00:00

abstract：:Lathyrus cicera copper amine oxidase (LCAO) rapidly formed the typical Cu(I)-TPQ semiquinone UV-visible spectrum, identical to that formed by other substrates, upon O(2) exhaustion by turnover with excess tryptamine. A new band at 630 nm formed more slowly, with intensity dependent on aldehyde and H(2)O(2) concentrati...

journal_title：Journal of inorganic biochemistry

authors： Pietrangeli P,Bellelli A,Fattibene P,Mondovì B,Morpurgo L

更新日期：2012-04-01 00:00:00

abstract：:The antioxidant activity of flavonoids may involve their ability to complex body iron in non-redox-active forms. In this study, it was found that the catechol flavonoids rutin and quercetin are able to suppress redox-active labile plasma iron (LPI) in both buffered solution and in iron-overloaded sera. Both flavonoids...

journal_title：Journal of inorganic biochemistry

authors： Baccan MM,Chiarelli-Neto O,Pereira RM,Espósito BP

更新日期：2012-02-01 00:00:00

abstract：:Nearly all microbes require iron for growth. The low concentration of iron found in the ocean makes iron acquisition a particularly difficult task. In response to these low iron conditions, many bacteria produce low-molecular-weight iron-binding molecules called siderophores to aid in iron uptake. We report herein the...

journal_title：Journal of inorganic biochemistry

authors： Gauglitz JM,Zhou H,Butler A

更新日期：2012-02-01 00:00:00

abstract：:Five new heterocyclic gold carbene complexes were prepared, four chlorido-[1,3-dimethyl-4,5-diarylimidazol-2-ylidene]gold complexes 6a-d and a chlorido-[1,3-dibenzylimidazol-2-ylidene]gold complex 11, and three of them were characterised by X-ray single crystal analyses. They were tested for cytotoxicity against a pan...

journal_title：Journal of inorganic biochemistry

authors： Kaps L,Biersack B,Müller-Bunz H,Mahal K,Münzner J,Tacke M,Mueller T,Schobert R

更新日期：2012-01-01 00:00:00

abstract：:Nickel-containing carbon monoxide dehydrogenases, acetyl-CoA synthases, nickel-iron hydrogenases, and diron hydrogenases are distinct metalloenzymes yet they share a number of important characteristics. All are O(2)-sensitive, with active-sites composed of iron and/or nickel ions coordinated primarily by sulfur ligand...

journal_title：Journal of inorganic biochemistry

authors： Lindahl PA

更新日期：2012-01-01 00:00:00

abstract：:A pair of chiral binuclear ruthenium(II) complexes were prepared and their binding affinities towards double stranded native DNA were assessed by observing isotropic absorption, polarized light spectra - circular and linear dichroism (CD and LD), fluorescence quenching and DNA thermal denaturation. Upon binding to DNA...

journal_title：Journal of inorganic biochemistry

authors： Chitrapriya N,Jang YJ,Kim SK,Lee H

更新日期：2011-12-01 00:00:00

abstract：:Copper(II) complexes with the non-steroidal anti-inflammatory drug diflunisal in the presence of N,N-dimethylformamide or nitrogen donor heterocyclic ligands (pyridine, 1,10-phenanthroline, 2,2'-bipyridine or 2,2'-bipyridylamine) have been synthesized and characterized. The deprotonated diflunisal ligands are coordina...

journal_title：Journal of inorganic biochemistry

authors： Fountoulaki S,Perdih F,Turel I,Kessissoglou DP,Psomas G

更新日期：2011-12-01 00:00:00

abstract：:The study of the reactivity of three 1-(2-dimethylaminoethyl)-1H-pyrazole derivatives of general formula [1-(CH(2))(2)NMe(2)}-3,5-R(2)-pzol] {where pzol represents pyrazole and R=H (1a), Me (1b) or Ph (1c)} with [MCl(2)(DMSO)(2)] (M=Pt or Pd) under different experimental conditions allowed us to isolate and characteri...

journal_title：Journal of inorganic biochemistry

authors： Quirante J,Ruiz D,Gonzalez A,López C,Cascante M,Cortés R,Messeguer R,Calvis C,Baldomà L,Pascual A,Guérardel Y,Pradines B,Font-Bardía M,Calvet T,Biot C

更新日期：2011-12-01 00:00:00

abstract：:In 1991, treatment with low dose intramuscular desferrioxamine (DFO), a trivalent chelator that can remove excessive iron and/or aluminum from the body, was reported to slow the progression of Alzheimer's disease (AD) by a factor of two. Twenty years later this promising trial has not been followed up and why this tre...

journal_title：Journal of inorganic biochemistry

authors： Percy ME,Kruck TP,Pogue AI,Lukiw WJ

更新日期：2011-11-01 00:00:00

abstract：:To investigate the structure-activity relationship of vanadium complexes in inhibiting protein tyrosine phosphatase1B (PTP1B), eight mixed-ligand oxovanadium(IV) complexes, [V(IV)O(SalAla)(NN)] (H(2)SalAla for salicylidene alanine, NN for N,N'-donor heterocyclic base, namely, 2,2'-bipyridine (bpy, 1), 1,10-phenanthrol...

journal_title：Journal of inorganic biochemistry

authors： Lu L,Yue J,Yuan C,Zhu M,Han H,Liu Z,Guo M

更新日期：2011-10-01 00:00:00

abstract：:Selenium (Se) influences the levels of selenoprotein W (SelW) in mammals. However, little is known about the pattern of SelW expression in the pancreatic tissue of birds. To investigate the effects of dietary Se levels on the expression of SelW mRNA in the pancreatic tissue of birds, one-day-old chickens were randomly...

journal_title：Journal of inorganic biochemistry

authors： Wang R,Sun B,Zhang Z,Li S,Xu S

更新日期：2011-09-01 00:00:00

abstract：:The nitrophorins (NP) of the adult blood-sucking insect Rhodnius prolixus fall into two pairs based on sequence identity (NP1,4 (90%) and NP2,3 (79%)), which differ significantly in the size of side chains of residues which contact the heme. These residues include those in the distal pocket of NP2 (I120) and NP1 (T121...

journal_title：Journal of inorganic biochemistry

authors： Shokhireva TK,Berry RE,Zhang H,Shokhirev NV,Walker FA

更新日期：2011-09-01 00:00:00

abstract：:In contrast to the comprehensive structural information about metal complexes with adenine, the corresponding to its isomer 2-aminopurine (H2AP) is extremely poor. With the aim to rationalize the metal binding pattern of H2AP, we report the molecular and/or crystal structure of four novel compounds with various iminod...

journal_title：Journal of inorganic biochemistry

authors： Domínguez-Martín A,Choquesillo-Lazarte D,González-Pérez JM,Castiñeiras A,Niclós-Gutiérrez J

更新日期：2011-08-01 00:00:00

abstract：:Root border cells (RBCs) and their secreted mucilage are suggested to participate in the resistance against toxic metal cations, including aluminum (Al), in the rhizosphere. However, the mechanisms by which the individual cell populations respond to Al and their role in Al resistance still remain unclear. In this rese...

journal_title：Journal of inorganic biochemistry

authors： Cai MZ,Wang FM,Li RF,Zhang SN,Wang N,Xu GD

更新日期：2011-07-01 00:00:00

abstract：:Three new binuclear copper(II) complexes have been synthesized and structurally characterized by X-ray crystallography, [Cu(2)(1,4-tpbd)(dafo)(2)(MeOH)(2)](ClO(4))(4)·2.5H(2)O (1), [Cu(2)(1,4-tpbd) (DMSO)(2)(ClO(4))(2)](OH)(2)·6H(2)O (2) and [Cu(2)(1,4-tpbd)(OAC)(2)(ClO(4))(2)]·5H(2)O (3) (1,4-tpbd=N,N,N',N'-tetrakis(...

journal_title：Journal of inorganic biochemistry

authors： Li DD,Tian JL,Gu W,Liu X,Zeng HH,Yan SP

更新日期：2011-06-01 00:00:00

abstract：:Supranutritional selenium (Se) intake and high serum Se levels have been associated epidemiologically with increased risk for type 2 diabetes, suggesting adverse effects of dietary Se compounds and/or antioxidant selenoenzymes on the sensitivity of target tissues for insulin. Here, we compared the capability of inorga...

journal_title：Journal of inorganic biochemistry

authors： Pinto A,Speckmann B,Heisler M,Sies H,Steinbrenner H

更新日期：2011-06-01 00:00:00

abstract：:It has been recently reported that pyrophosphate, tri-polyphosphate, ATP and analogous ligands considerably decrease the yield of hydroxyl radicals by the Fenton reaction under conditions where [H(2)O(2)]>[Fe(II)L(n)]. It was suggested that this effect is due to the slowing down of the Fenton reaction by these ligands...

journal_title：Journal of inorganic biochemistry

authors： Rachmilovich-Calis S,Masarwa A,Meyerstein N,Meyerstein D

更新日期：2011-05-01 00:00:00

abstract：:Thioredoxin (Trx1), a very important protein for regulating intracellular redox reactions, was immobilized on iron oxide superparamagnetic nanoparticles previously coated with 3-aminopropyltriethoxysilane (APTS) via covalent coupling using the EDC (1-ethyl-3-{3-dimethylaminopropyl}carbodiimide) method. The system was ...

journal_title：Journal of inorganic biochemistry

authors： Netto CG,Nakamatsu EH,Netto LE,Novak MA,Zuin A,Nakamura M,Araki K,Toma HE

更新日期：2011-05-01 00:00:00

abstract：:Nine recombinant FixL heme domains from Bradyrhizobium japonicum previously were shown to exhibit mass instability independent of many environmental factors (J.D. Satterlee, C. Suquet, A. Bidwai, J. Erman, L. Schwall, R. Jimenez, Biochemistry 47 (2008) 1540-1553). Two of those recombinant proteins were produced in rem...

journal_title：Journal of inorganic biochemistry

authors： Satterlee JD

更新日期：2011-05-01 00:00:00

abstract：:The novel steroidal carrier ligand 17-α-[4'-ethynyl-dimethylbenzylamine]-17-β-testosterone (ET-dmba 1) and the steroid--C,N-chelate platinum(II) derivatives [Pt(ET-dmba)Cl(L)] (L = DMSO (2) and PTA (3; PTA =1,3,5-triaza-7-phosphaadamantane)) have been prepared. Values of IC(50) were calculated for the new platinum com...

journal_title：Journal of inorganic biochemistry

authors： Ruiz J,Rodríguez V,Cutillas N,Espinosa A,Hannon MJ

更新日期：2011-04-01 00:00:00

abstract：:The synthesis, crystal structures, physicochemical properties and complex formation constants of [Cu(phen)(2)(L)](ClO(4))(2) complexes, where phen is 1,10-ortho-phenanthroline and L is a series of substituted imidazolidine-2-thione, have been studied. Single crystal X-ray diffraction revealed a distorted trigonal-bipy...

journal_title：Journal of inorganic biochemistry

authors： Pivetta T,Cannas MD,Demartin F,Castellano C,Vascellari S,Verani G,Isaia F

更新日期：2011-03-01 00:00:00

abstract：:Three binuclear Ru(II) complexes with two [Ru(bpy)(2)(pip)](2+)-based subunits {where bpy=2,2'-bipyridine and pip=2-phenylimidazo[4,5-f][1,10]phenanthroline} being linked by varied lengths of flexible bridges, were synthesized and characterized by (1)H NMR, elemental analysis, UV-visible (UV-vis) and photoluminescence...

journal_title：Journal of inorganic biochemistry

authors： Ju CC,Zhang AG,Yuan CL,Zhao XL,Wang KZ

更新日期：2011-03-01 00:00:00

abstract：:Since its discovery, nitric oxide synthase (NOS), the enzyme responsible for NO biosynthesis in mammals, has been the subject of extensive investigations regarding its catalytic and molecular mechanisms. These studies reveal the high degree of sophistication of NOS functioning and regulation. However, the precise desc...

journal_title：Journal of inorganic biochemistry

authors： Santolini J

更新日期：2011-02-01 00:00:00

abstract：:The N-terminal protected and unprotected peptides MAHHEEQHG-NH(2), Ac-MAHHEEQHG-NH(2) from Hpn (Helicobacter histidine-rich protein) and MAHHEQQQQQQA-NH(2), Ac-MAHHEQQQQQQA-NH(2) from Hpn-like protein, respectively, were synthesized and their interactions with Cu(2+) and Ni(2+) ions were studied by potentiometric, UV-...

journal_title：Journal of inorganic biochemistry

authors： Witkowska D,Bielinska S,Kamysz W,Kozlowski H

更新日期：2011-02-01 00:00:00